Southern rockers Jason Isbell of Drive-by Truckers fame has joined his wife violinist Amanda Shires for a weekly at-home variety show entitled I So Lounge.

This week, the husband and wife were joined by keyboardist Peter Levin for a trio of songs including “Ariel Ramirez” by Richard Buckner, “Beth” by Bon Iver and “Layla” by Eric Clapton’s Derek and the Dominoes.

After a false start, the trio performs a beautiful rendition of the timeless classic that turns 50 this year.

Thanks to Amanda Shires for the footage!